Objective To explore the correlation between social support and occupational burnout and mental health of nursing interns so as to provide scientific basis for reducing occupational burnout and improving mental health level. Methods It randomly selected 635 nursing students in grade 2013 interns from three high vocational colleges in Baoji area as the research object. It adopted Chinese version social support rating scale(SSRS)of LI Chao-ping revision(MBI-GS),symptom self-assessment scale(SCL-90)and self-designed professional related factors questionnaire to investigate. Results 1. the detection rate of negative occupational factors in male nursing students was higher than that in female(P value <0.05). 2. In addition to objective support,total average score and all other dimensions in male nurses support was lower than that in female nurses(P value<0.01),and job burnout was higher than that of female nursing students(P<0.01). 3. The score of anxiety,hostility and bigotry in male nursing students was higher than that in female(P value<0.05). In four-factor score like interpersonal sensitive,depression,anxiety and bigotry was higher than that in national college student norm in 2009(P value was<0.05). 4. In addition to subjective support in male and female nursing interns,support total score and other dimension score showed negative correlation. The score of four-factors like interpersonal sensitive,depression,anxiety and bigotry,total score of social support and the score of each dimension showed negative correlation. 5. Regression analysis showed that family income had the most predictive power to occupational burnout. Only child had the most predictive power to mental health. Conclusions Nursing interns in higher vocational college have low social support and high incidence of job burnout,and special seriousness in male nursing interns,and worry about their mental health.