This paper introduces how does the regional health digital construction represented by Xuhui District cope with and meet the digital transformation in the health field under the background of digital transformation,including the functional positioning,organizational structure and construction process of regional health digital construction. While expounding the practical experience of the organic combination of theory and practice,it also points out the unique advantages and major necessity of digital construction at the regional level,so as to promote the efficiency and high-quality of digital construction work.